#Supriya prasanth full#
A small percentage of scholars at each level of tenured faculty promotion (associate professor and full professor) are selected to receive Campus Distinguished Promotion Awards. Defects in accurate replication and faithful chromosome segregation cause genomic instability, a hallmark of all cancers. The funding for this study was provided by National Science Foundation, and The Leukemia and Lymphoma Society, through a Special Fellow Award granted to Supriya Prasanth.During its annual promotion review process, the Campus Committee on Promotion and Tenure identifies exceptional cases of scholars whose contributions have been extraordinary in terms of quality of work and overall achievement. Supriya Prasanth’s laboratory is focused on understanding how replication initiation is coordinated with chromatin organization and cell cycle progression. Other Illinois researchers on the study include Kannanganattu Prasanth, a professor in the department of cell and developmental biology his graduate student Ruiping Zheng Brian Freeman, a professor in the department of cell and developmental biology Fei Wang, a professor in cell and developmental biology and his graduate student Yejie Geng. The study was spearheaded by Zhen Shen, a graduate student, with assistance from post-doctoral fellows Kizhakke M. This work is going to have important implications in cancer biology." "We all know that diseases like cancer are caused by uncontrolled proliferation of cells, and our data demonstrates that ORCA controls proliferation of cells. Using multi-disciplinary approaches, the Prasanth lab examines how. Kaustuv Sanyal Molecular Mycology Laboratory Molecular Biology and Genetics Unit Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore, India. Yijun Qi School of Life Sciences Tsinghua University Beijing, China. "The discovery of this new protein is going to be revolutionary in the field of replication and cell cycle," Prasanth said. Supriya Prasanth’s laboratory is focused on understanding how replication initiation is coordinated with chromatin organization and cell cycle progression. Supriya Prasanth University of Illinois at Urbana-Champaign, Department of Cell and Developmental Biology Urbana, IL, USA.
This work appears in the Octoissue of the journal Molecular Cell. Jie Chen, Head of Cell and Developmental Biology With Dr. These results suggest that a novel protein, ORCA, is critical for initiation of DNA replication and heterochromatin organization in mammalian cells. Prasanth receives Research Excellence Award from the School of Molecular and Cellular Biology. Departmental faculty are concerned with the structural and functional relationships of cells and organisms, with research emphases upon eukaryotic cell and molecular biology, developmental.
Loss of ORCA results in defects in cellular proliferation, suggesting that a fine-tuned balance in the levels of ORCA is maintained in a normal cell. The graduate curriculum in Cell and Developmental Biology is designed to educate students for careers in research and teaching in the biological sciences. Depletion of ORCA in human primary cells as well as in embryonic stem cells results in the loss of ORC binding to chromatin and subsequent arrest of cells in a vital phase of the cell cycle. The researchers further demonstrated that ORCA efficiently recruits ORC to chromatin, the DNA and proteins that make up the chromosome. Along with ORC, this protein binds to heterochromatic structures, including centromeres and telomeres, which are important to cell division and chromosome maintenance. Join Facebook to connect with Supriya Prasanth Supriya Prasanth and others you may. They have shown that in human cells, this protein (once known as LRWD1 but renamed ORCA, for "ORC-associated" protein) associates with ORC and shows similar cell cycle dynamics to ORC. View the profiles of people named Supriya Prasanth Supriya Prasanth. Researchers at the University of Illinois, led by Professor Supriya Prasanth from the school of molecular and cellular biology, have identified a novel protein that is highly conserved in higher eukaryotes. How ORC is brought to the DNA in human cells had previously remained a mystery. In addition to its role in DNA replication, ORC is also involved in gene silencing and organization of the tightly packed DNA, called heterochromatin.